Identification and biological activity of microbial metabolites of xanthohumol

被引：25
|
作者：
Herath, W
Ferreira, D
Khan, SI
Khan, IA [1 ]
机构：
[1] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
[2] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 11期
关键词：
xanthohumol; microbial metabolite; chalcone; NMR; antimalarial;
D O I：
10.1248/cpb.51.1237
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Microbial transformation of xanthohumol using the culture broth of Cunninghamella echinulata NRRL 3655 afforded (2S)-8-[4"-hydroxy-3"-methyl-(2"-Z)-butenyl]-4',7-dihydroxy-5-methoxyflavanone (5) and (2s)-8-[5"-hydroxy-3"-methyl-(2"-E)-butenyl]-4',7-dihydroxy-5-methoxyflavanone (6). Xanthohumol (1) and flavanone 6 as well as (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":4',3']-2',4-dihydroxy-6'-methoxychalcone (2), (2S)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2"',3":7,8]-4'-hydroxy-5-methoxyflavanone (3) obtained with Pichia membranifaciens showed antimalarial activity against Plasmodium falciparum.
引用
收藏
页码：1237 / 1240
页数：4
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