RIFM fragrance ingredient safety assessment, 2-methyl-5-(methylthio)furan, CAS Registry Number 13678-59-6

被引：0

作者：

Api, A. M. ^{[1
]}

Belsito, D. ^{[2
]}

Botelho, D. ^{[1
]}

Bruze, M. ^{[3
]}

Burton, G. A., Jr. ^{[4
]}

Cancellieri, M. A. ^{[1
]}

Chon, H. ^{[1
]}

Dagli, M. L. ^{[5
]}

Date, M. ^{[1
]}

Dekant, W. ^{[6
]}

Deodhar, C. ^{[1
]}

Fryer, A. D. ^{[7
]}

Jones, L. ^{[1
]}

Joshi, K. ^{[1
]}

Kumar, M. ^{[1
]}

Lapczynski, A. ^{[1
]}

Lavelle, M. ^{[1
]}

Lee, I. ^{[1
]}

Liebler, D. C. ^{[8
]}

Moustakas, H. ^{[1
]}

Na, M. ^{[1
]}

Penning, T. M. ^{[9
]}

Ritacco, G. ^{[1
]}

Romine, J. ^{[1
]}

Sadekar, N. ^{[1
]}

Schultz, T. W. ^{[10
]}

Selechnik, D.

Siddiqi, F. ^{[1
]}

Sipes, I. G. ^{[11
]}

Sullivan, G. ^{[1
]}

Thakkar, Y. ^{[1
]}

Tokura, Y. ^{[12
]}

机构：

[1] Res Inst Fragrance Mat Inc, 50 Tice Blvd, Woodcliff Lake, NJ 07677 USA

[2] Columbia Univ, Dept Dermatol, Member Expert Panel Fragrance Safety, Med Ctr, 161 Ft Washington Ave, New York, NY 10032 USA

[3] Malmo Univ Hosp, Dept Occupat Environm Dermatol, Member Expert Panel Fragrance Safety, Sodra Forstadsgatan 101,Entrance 47, SE-20502 Malmo, Sweden

[4] Univ Michigan, Sch Nat Resources Environm, Member Expert Panel Fragrance Safety, Dana Bldg G110,440 Church St, Ann Arbor, MI 48109 USA

[5] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Member Expert Panel Fragrance Safety, Ave Prof Dr Orlando Marques Paiva 87, BR-05508900 Sao Paulo, Brazil

[6] Univ Wurzburg, Dept Toxicol, Member Expert Panel Fragrance Safety, Versbacher Str 9, D-97078 Wurzburg, Germany

[7] Oregon Hlth & Sci Univ, Member Expert Panel Fragrance Safety, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[8] Vanderbilt Univ, Dept Biochem, Ctr Mol Toxicol, Member Expert Panel Fragrance Safety,Sch Med, 638 Robinson Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA

[9] Univ Penn, Perelman Sch Med, Ctr Excellence Environm Toxicol, Member Expert Panel Fragrance Safety, 1316 Biomed Res Bldg BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA

[10] Univ Tennessee, Dept Comparat Med, Coll Vet Med, Member Expert Panel Fragrance Safety, 2407 River Dr, Knoxville, TN 37996 USA

[11] Univ Arizona, Dept Pharmacol, Coll Med, Member Expert Panel Fragrance Safety, 1501 North Campbell Ave,POB 245050, Tucson, AZ 85724 USA

[12] Hamamatsu Univ, Dept Dermatol, Member Expert Panel Fragrance Safety, Journal Dermatol Sci JDS,Sch Med, 1-20-1 Handayama,Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2022年 / 167卷

关键词：

DERMAL SENSITIZATION THRESHOLD; PERSONAL CARE; DST APPROACH; CONSUMER EXPOSURE; COSMETICS; CHEMICALS; DATASET; MODEL; TTC;

D O I：

10.1016/j.fct.2022.113339

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The existing information supports the use of this material as described in this safety assessment. 2-Methyl-5-(methylthio)furan was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-methyl-5-(methylthio)furanis not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-methyl-5-(methylthio)furanis below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 mu g/cm(2)); exposure is below the DST. The photoirritation/photoallergenicity endpoints were evaluated based on data and ultraviolet/visible (UV/Vis) spectra; 2-methyl-5-(methylthio)furanis not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 2-methyl-5-(methylthio)furan was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

引用

页数：7

共 50 条

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