Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma

被引：17
|
作者：
Machaczka, Maciej [1 ,3 ]
Vaktnas, Johan [3 ]
Klimkowska, Monika [2 ]
Nahi, Hareth [1 ]
Hagglund, Hans [1 ]
机构：
[1] Karolinska Univ, Huddinge Hosp, Hematol Ctr Karolinska, S-14186 Stockholm, Sweden
[2] Karolinska Univ, Huddinge Hosp, Dept Pathol, S-14186 Stockholm, Sweden
[3] Varberg Hosp, Dept Med, Hematol Sect, Varberg, Sweden
来源：
MEDICAL ONCOLOGY | 2011年 / 28卷 / 02期
关键词：
Hemophagocytosis; Hemophagocytic lymphohistiocytosis; Hemophagocytic syndrome; Multiple myeloma; Epilepsy; Anticonvulsants; CLINICAL-FEATURES; CHILDREN;
D O I：
10.1007/s12032-010-9484-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.
引用
收藏
页码：539 / 543
页数：5
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