Peripheral blood CD38 expression predicts survival in B-cell chronic lymphocytic leukemia

被引：48
|
作者：
Morabito, F [1 ]
Mangiola, M
Oliva, B
Stelitano, C
Callea, V
Deaglio, S
Iacopino, P
Brugiatelli, M
Malavasi, F
机构：
[1] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Ctr Trapianti Midollo Osseo, I-89100 Reggio Di Calabria, Italy
[2] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Div Ematol, I-89100 Reggio Di Calabria, Italy
[3] Azienda Osped Bianchi Melacrino Morelli, Dipartimento Ematol, Ctr Microcitemie, I-89100 Reggio Di Calabria, Italy
[4] Univ Turin, Dipartimento Biol Genet & Biochim, Turin, Italy
来源：
LEUKEMIA RESEARCH | 2001年 / 25卷 / 11期
关键词：
B-CLL; CD38; survival; prognosis; monoclonal antibody;
D O I：
10.1016/S0145-2126(01)00049-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CD38 expression was investigated in 161 untreated patients with B-cell chronic lymphocytic leukemia (B-CLL). A score system, devised ad hoc by integrating the percentage and the mean fluorescence intensity (MFI) values of CD38(+) cells, indicated that B-CLL patients with a CD38 score less than or equal to 3 are characterized by a significantly longer survival compared to those with a CD38 score > 3 (P = 0.0026). Thirty-seven percent of patients with a CD38 score less than or equal to 3 and 58% of those with a score > 3 were dead at 10 years. Multivariate analysis indicates that only the CD38 score successfully predicts survival (P = 0.0028), with an estimated 3.8-fold greater risk of death for those cases with CD38 score > 3. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：927 / 932
页数：6
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