Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea

被引:11
|
作者
Smith, David F. [1 ,2 ,3 ,4 ,5 ]
Schuler, Christine L. [2 ,3 ,6 ,7 ]
Hossain, Md M. [7 ,8 ]
Huang, Guixia [8 ]
McConnell, Keith [2 ,3 ]
Urbina, Elaine M. [7 ,9 ]
Amin, Raouf S. [2 ,3 ,7 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Pediat Otolaryngol Head & Neck Surg, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Pulm Med, 3333 Burnet Ave, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Sleep Ctr, Cincinnati, OH 45229 USA
[4] Cincinnati Childrens Hosp Med Ctr, Ctr Circadian Med, Cincinnati, OH 45229 USA
[5] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Coll Med, Cincinnati, OH USA
[6] Cincinnati Childrens Hosp Med Ctr, Div Hosp Med, Cincinnati, OH 45229 USA
[7] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
[8] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA
[9] Cincinnati Childrens Hosp Med Ctr, Heart Inst, Cincinnati, OH 45229 USA
来源
JOURNAL OF PEDIATRICS | 2021年 / 239卷
基金
美国国家卫生研究院;
关键词
INTIMA-MEDIA THICKNESS; BLOOD-PRESSURE; RISK-FACTOR; ASSOCIATION; MARKERS; EVENTS; OBESITY;
D O I
10.1016/j.jpeds.2021.08.031
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To evaluate structural and functional carotid changes and inflammatory profiles in children with obstructive sleep apnea (OSA) and healthy controls. Study design Patients with OSA and matched controls (ages 5-13 years) were recruited. Proinflammatory cytokines and acute phase reactants were measured at 6:00 p.m. Common carotid artery measures were determined using ultrasound. Confirmatory factor analysis was used to determine subgroups of cytokines and their effects on carotid measures. Results Ninety-six patients participated (53 healthy controls, 43 patients with OSA). OSA was associated with increased proinflammatory cytokines (cluster of differentiation-40 ligand [CD40-L], interleukin [IL]-6, and IL-8) and high sensitivity C-reactive protein (P < .05 for all). One cytokine subgroup (IL-6 and IL-8) was negatively associated with markers of carotid function, indicating reduced arterial distensibility and increased stiffness (P < .05 for 3 ultrasound measures); and tumor necrosis factor-alpha had an opposing effect on carotid function compared with this cytokine subgroup (P < .05 for 2 ultrasound measures). Linear regression demonstrated significant associations between and tumor necrosis factor-alpha and 2 measures of carotid function (P < .05 for each). Children with OSA did not have functional or structural carotid changes compared with controls. Conclusion OSA was not directly associated with structural and functional carotid changes but was associated with upregulation of key proinflammatory cytokines (sCD40-L, IL-6, and IL-8). Together, IL-6 and IL-8 were associated with changes in carotid function. Longitudinal studies are needed to demonstrate that the inflammatory milieu observed in our population is a precursor of atherosclerosis in children.
引用
收藏
页码:168 / 174
页数:7
相关论文
共 50 条
  • [1] Inflammatory markers in children with obstructive sleep apnea syndrome
    Wang, Yingge
    Chen, Ying
    Lin, Wei
    Huang, Min
    Xu, Yuanteng
    Chen, Guohao
    FRONTIERS IN PEDIATRICS, 2023, 11
  • [2] Anti-inflammatory therapy for obstructive sleep apnea in children
    Friedman, Bat-Chen
    Goldman, Ran D.
    CANADIAN FAMILY PHYSICIAN, 2011, 57 (08) : 891 - 893
  • [3] Atherosclerotic phenotype of monocytes in obstructive sleep apnea
    Golan-Shany, O.
    Dyugovskaya, L.
    Lavie, P.
    Lavie, L.
    JOURNAL OF SLEEP RESEARCH, 2008, 17 : 163 - 163
  • [4] Anti-inflammatory medications for obstructive sleep apnea in children
    Kuhle, Stefan
    Urschitz, Michael S.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (01):
  • [5] Inflammatory Milieu and Cardiovascular Homeostasis in Children With Obstructive Sleep Apnea
    Smith, David F.
    Hossain, Md M.
    Hura, Arjan
    Huang, Guixia
    McConnell, Keith
    Ishman, Stacey L.
    Amin, Raouf S.
    SLEEP, 2017, 40 (04)
  • [6] Atherosclerotic phenotype of monocytes in obstructive sleep apnea
    Lavie, L.
    Golan-Shany, O.
    Dyugovskaya, L.
    Lavie, P.
    SLEEP, 2008, 31 : A140 - A140
  • [7] Obstructive sleep apnea in children
    Sommer, J. U.
    Stuck, B. A.
    Maurer, J. T.
    HNO, 2010, 58 (12) : 1217 - 1225
  • [8] Obstructive Sleep Apnea in Children
    Tripuraneni, Manasa
    Paruthi, Shalini
    Armbrecht, Eric S.
    Mitchell, Ron B.
    LARYNGOSCOPE, 2013, 123 (05): : 1289 - 1293
  • [9] Obstructive sleep apnea in children
    Chan, J
    Edman, JC
    Koltai, PJ
    AMERICAN FAMILY PHYSICIAN, 2004, 69 (05) : 1147 - 1154
  • [10] Obstructive sleep apnea in children
    Hoban T.F.
    Current Treatment Options in Neurology, 2005, 7 (5) : 353 - 361