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Univ Amsterdam, Med Ctr, Tytgat Inst Liver & Intestinal Res, Dept Gastroenterol & Hepatol, Locat AMC,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam, Med Ctr, Tytgat Inst Liver & Intestinal Res, Dept Gastroenterol & Hepatol, Locat AMC,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands