Enantioselective Palladium-Catalyzed Carbozincation of Cyclopropenes

被引：74
|
作者：
Kraemer, Katja [1 ]
Leong, Paul [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
OXABICYCLIC ALKENES; GRIGNARD-REAGENTS; DERIVATIVES; CARBOMETALATION; CHEMISTRY; ADDITIONS;
D O I：
10.1021/ol1029904
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective palladium-catalyzed carbozincation of cyclopropenes has been developed. The intermediate cyclopropylzinc species, after transmetalation with copper, were trapped with various electrophiles. This one-pot procedure furnished functionalizied cyclopropenes with excellent diastereo- and enantioselectivity.
引用
收藏
页码：819 / 821
页数：3
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