Hydrogen Acceptor- and Base-Free N-Formylation of Nitriles and Amines using Methanol as C1 Source

被引：74
|
作者：
Kang, Byungjoon [1 ,2 ]
Hong, Soon Hyeok [1 ,2 ]
机构：
[1] Seoul Natl Univ, Coll Nat Sci, Dept Chem, Seoul 151747, South Korea
[2] Korea Carbon Capture Sequestrat R&D Ctr KCRC, Taejon 305303, South Korea
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
formylation; homogeneous catalysis; N-heterocyclic carbenes; ruthenium; AMIDE SYNTHESIS; AEROBIC OXIDATION; SECONDARY-AMINES; GREEN CHEMISTRY; CATALYZED ALDOL; ATOM ECONOMY; RUTHENIUM; ALCOHOLS; DEHYDROGENATION; CARBONYLATION;
D O I：
10.1002/adsc.201400982
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An N-formylation method using methanol as the C-1 source without a stoichiometric amount of activating reagent is described. Nitriles as well as amines can be directly used as substrates. The reaction is catalyzed by an N-heterocyclic carbene coordinated ruthenium(II) dihydride complex, which mediates methanol dehydrogenation, nitrile reduction, and C-N bond formation without any external base, hydrogen acceptor, or oxidant.
引用
收藏
页码：834 / 840
页数：7
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