STK-002, an Antisense Oligonucleotide (ASO) for the Treatment of Autosomal Dominant Optic Atrophy (ADOA), is Taken Up by Retinal Ganglion Cells (RGC) and Upregulates OPA-1 Protein Expression After Intravitreal Administration to Non-human Primates (NHPs)

被引：0

|

作者：

Anderson, Karen ^{[1
]}

Venkatesh, Aditya ^{[1
]}

McKenty, Taylor ^{[1
]}

Slate, Deidre ^{[1
]}

Lin, Qian ^{[1
]}

Ravipaty, Shobha ^{[1
]}

Jacobson, Sarah ^{[1
]}

Christiansen, Anne ^{[1
]}

Benmohamed, Radhia ^{[1
]}

Hoger, Jeff ^{[1
]}

Liau, Gene ^{[1
]}

机构：

[1] Stoke Therapeut Inc, Bedford, MA USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2022年 / 63卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

1111

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收藏

页数：3

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[1] STK-002, an Antisense Oligonucleotide (ASO) for the Treatment of Autosomal Dominant Optic Atrophy (ADOA), Localizes to Retinal Ganglion Cells (RGC) and Upregulates OPA-1 Protein Expression After Intravitreal Administration to Non-Human Primates (NHP)
Venkatesh, Aditya
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Slate, Deidre
Lin, Qian
Ravipaty, Shobha
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Hoger, Jeff
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MOLECULAR THERAPY, 2022, 30 (04) : 9 - 9
[2] Antisense Oligonucleotide STK-002 Increases OPA1 in Retina and Improves Mitochondrial Function in Autosomal Dominant Optic Atrophy Cells
Venkatesh, Aditya
McKenty, Taylor
Ali, Syed
Sonntag, Donna
Ravipaty, Shobha
Cui, Yanyan
Slate, Deirdre
Lin, Qian
Christiansen, Anne
Jacobson, Sarah
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Lim, Kian Huat
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Zinshteyn, Boris
Aznarez, Isabel
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