The present study aimed to evaluate the relation between mortality and admission heart rate in patients treated with primary angioplasty (PA) for acute myocardial infarction (AMI). We included 308 patients (mean age 63 years, 83% men) who underwent PA for AMI admitted <12 hours after symptom onset. The population was divided into three groups with respect to admission HR: A (50 to 100 bpm), B (<50 bpm), and C (>100 bpm). Univariate analysis followed by logistic regression was performed using the variables linked to mortality in the univariate analysis to assess the relation between predictor variables and in-hospital mortality. The in-hospital mortality rate was 11%. There was significant relation between the admission HR and in-hospital mortality (p=0.000). Mortality rate was 6% in group A, 17% in group B, and 27% in group C. After logistic regression, age (OR 1.05 per year, (95% CI: 1.01-1.09)), Killip IV 4.1 (1.4-12.2), ST-resolution 3.2 (1.1-9.1), time between hospital admission and CPK-peak 1.05 (1.0-1.1) per hour, and admission HR higher 100 bpm 3.8 (1.4-10.8) were independently correlated with in-hospital mortality. This study demonstrates that elevated admission HR is an independent predictor of in-hospital mortality in patients with AMI who underwent PA.