Analgesic Efficacy of Tramadol and Morphine in White's Tree Frogs (Litoria caerulea)

被引:2
|
作者
Hausmann, Jennifer C. [1 ,3 ]
Krisp, Ashley R. [1 ,4 ]
Mans, Christoph [1 ]
Johnson, Stephen M. [2 ]
Sladky, Kurt K. [1 ]
机构
[1] Univ Wisconsin, Dept Surg Sci, Sch Vet Med, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53706 USA
[3] Denver Zoo, Denver, CO USA
[4] Bluemound Anim Hosp, Brookfield, WI USA
关键词
XYLAZINE HYDROCHLORIDE; FLUNIXIN MEGLUMINE; BUTORPHANOL; POTENCY; MU; NOCICEPTION; MELOXICAM;
D O I
10.30802/AALAS-JAALAS-21-000009
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Published data are sparse regarding the recognition of clinically relevant pain and appropriate analgesia in amphibians. The amphibian analgesia literature has primarily focused on nociceptive pathways in a single species, the northern leopard frog (Rana pipiens). The objective of the current study was to assess the analgesic efficacy and safety of oral tramadol and subcutaneous morphine in a commonly maintained zoo and pet species, White's tree frog (Litoria caerulea). We hypothesized that tramadol and morphine would provide dose-dependent antinociception, as measured by significant increases in hindlimb withdrawal latency after exposure to a noxious thermal stimulus. Two randomized, placebo-controlled, complete crossover studies were performed, with tramadol (n = 12) administered at 15, 25, and 40 mg/kg PO and morphine (n = 12) administered at 5 and 10 mg/kg SC. Hindlimb withdrawal latency was measured for a maximum of 72 h. No adverse side effects or signs of sedation were observed with any dose or drug evaluated. No significant difference in withdrawal latency was detected between the control and either tramadol or morphine. These negative results were surprising, suggesting that the thermal nociceptive model may not be biologically relevant in amphibian species.
引用
收藏
页码:681 / 686
页数:6
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