Temsirolimus for Metastatic Desmoplastic Small Round Cell Tumor

被引：32

作者：

Thijs, Anna M. J. ^{[1
]}

van der Graaf, Winette T. A. ^{[1
]}

van Herpen, Carla M. L. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 07期

关键词：

desmoplastic small round cell tumor; mTOR inhibition; sarcoma; targeted therapy; temsirolimus; EMPHASIS;

D O I：

10.1002/pbc.22755

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Desmoplastic small round cell tumor (DSRCT) is a rare and round cell tumors in which the EWS gene is fused to the WT1 gene aggressive neoplasm that mostly occurs in young males No curative We therefore demonstrate the prolonged activity of temsirolimus, an treatment options currently exist for this type of tumor and long mTOR inhibitor in a patient with DSRCT Pediatr Blood Cancer term survival remains poor In vitro rapamycin induces apoptotic 2010 55 1431-1432 (C) 2010 Wiley Liss Inc death of JN DSRCT 1 cells a possible model for desmoplastic small

引用

页码：1431 / 1432

页数：2

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