Emerging CAR T cell therapies: clinical landscape and patent technological routes

被引:12
|
作者
Picanco-Castro, Virginia [1 ]
Pereira, Cristiano Goncalves [2 ]
Swiech, Kamilla [1 ,3 ]
Ribeiro Malmegrim, Kelen Cristina [1 ,3 ]
Covas, Dimas Tadeu [1 ]
Porto, Geciane Silveira [2 ,4 ]
机构
[1] Univ Sao Paulo, Ctr Cell Based Therapy CTC, Reg Blood Ctr Ribeirao Preto, Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Sch Econ Business Adm & Accounting, Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, Brazil
[4] Univ Sao Paulo, Inst Adv Studies, Ribeirao Preto, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
Patent landscape; technology forecasting; clinical trials; CAR-T cells; ADOPTIVE IMMUNOTHERAPY; ANTIGEN; LYMPHOMA; ANTIBODY; IMMUNOGLOBULIN; COSTIMULATION; PERSISTENCE; LYMPHOCYTES; ACTIVATION; EXPRESSION;
D O I
10.1080/21645515.2019.1689744
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The purpose of this study is to mine CAR-T patents and therapies under development, to design a landscape of the sector and to understand key therapy segments and their current trends. The study analyzed the entire market, consisting of 1624 patent families and 509 biologics under development, to depict an overview of the CAR-T therapies and their state of the art. Our results showed cutting-edge inventions, the major players, the dynamics of cooperation among institutions, the progress of the therapies' generation over the years and future innovation pathways. CAR-T therapies are transforming the current scenario for cancer treatment, and this study reveals the picture of what we can likely expect ahead in order to assist scientists at the academy and industry to improve their research strategies.
引用
收藏
页码:1424 / 1433
页数:10
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