Second-generation antimalarial endoperoxides

被引：91

作者：

Meshnick, SR

Jefford, CW

Posner, GH

Avery, MA

Peters, W

机构：

[1] UNIV GENEVA,DEPT ORGAN CHEM,CH-1211 GENEVA,SWITZERLAND

[2] JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218

[3] UNIV MISSISSIPPI,DEPT MED CHEM,UNIVERSITY,MS 38677

[4] UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109

[5] CAB INT,INST PATHOL,ST ALBANS AL4 0XU,ENGLAND

来源：

PARASITOLOGY TODAY | 1996年 / 12卷 / 02期

关键词：

D O I：

10.1016/0169-4758(96)80660-0

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Artemisinin, derived from a Chinese herbal remedy, is a potent peroxide-containing antimalarial. New types of peroxides, derived from this structure, as well as other naturally occurring antimalarial peroxides, have been synthesized and found to have potent antimalarial activities. Studies on the activities, modes of action, and toxicities of these compounds are discussed here by Steven Meshnick and colleagues.

引用

页码：79 / 82

页数：4

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