(11aS)-7-Bromo-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione

被引：1
|
作者：
Ma, Chao [2 ]
Wang, Zhen-Zhong [1 ]
Pan, Li [2 ]
Tian, Yu [2 ]
Xiao, Wei [1 ]
机构：
[1] Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2012年 / 68卷
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
PYRROLO<2,1-C><1,4>BENZODIAZEPINES; DC-81;
D O I：
10.1107/S1600536811052962
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, C12H11BrN2O2, was prepared by an intra-cyclization reaction of (S)-1-(5-bromo-2-nitrobenzyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester in the presence of EtOH/Fe. The five-membered pyrrolidinone ring adopts an approximate envelope conformation, while the seven-membered diazepanone ring displays a twisted boat conformation. Intermolecular classical N-H center dot center dot center dot O hydrogen bonds and weak C-H center dot center dot center dot O interactions help to stabilize the crystal structure.
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页数：9
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