5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

被引：186

作者：

Kellinger, Matthew W. ^{[1
]}

Song, Chun-Xiao ^{[2
,3
]}

Chong, Jenny ^{[1
]}

Lu, Xing-Yu ^{[2
,3
]}

He, Chuan ^{[2
,3
]}

Wang, Dong ^{[1
]}

机构：

[1] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA

[2] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

[3] Univ Chicago, Inst Biophys Dynam, Chicago, IL USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 08期

基金：

美国国家卫生研究院;

关键词：

THYMINE DNA GLYCOSYLASE; STRUCTURAL BASIS; MAMMALIAN DNA; 5-METHYLCYTOSINE; REPAIR; 5-HYDROXYMETHYLCYTOSINE; DEMETHYLATION; METHYLATION; EXCISION;

D O I：

10.1038/nsmb.2346

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the roles of 5-methylcytosine and 5-hydroxymethylcytosine in epigenetic regulation of gene expression are well established, the functional effects of 5-formylcytosine and 5-carboxylcytosine on the process of transcription are not clear. Here we report a systematic study of the effects of five different forms of cytosine in DNA on mammalian and yeast RNA polymerase II transcription, providing new insights into potential functional interplay between cytosine methylation status and transcription.

引用

页码：831 / 833

页数：3

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