Catalytic enantioselective passerini three-component reaction

被引：117
|
作者：
Wang, Shi-Xin [1 ]
Wang, Mei-Xiang [1 ]
Wang, De-Xian [1 ]
Zhu, Jieping [2 ]
机构：
[1] Chinese Acad Sci, Biol Chem Lab, Inst Chem, Natl Lab Mol Sci, Beijing 100080, Peoples R China
[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 02期
关键词：
aluminum; asymmetric catalysis; isocyanides; multicomponent reactions; salen ligands;
D O I：
10.1002/anie.200704315
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Make it enantioselective: The [(salen)-AlIIICl] complex 1 catalyzes the title reaction of an aldehyde, a carboxylic acid, and an isocyanide to afford α-acyloxyamides 2 with good to excellent enantioselectivity. A variety of nonchelating substrates can be used to generate the versatile chiral products. R1 = alkyl; R2 = alkyl, alkenyl, aryl; R3 = alkyl, aryl. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：388 / 391
页数：4
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