Incorporation of choline into Streptococcus pneumoniae cell wall antigens: Evidence for choline kinase activity

被引：19
|
作者：
Whiting, GC [1 ]
Gillespie, SH [1 ]
机构：
[1] ROYAL FREE HOSP,SCH MED,DEPT MED MICROBIOL,LONDON NW3 2PF,ENGLAND
来源：
FEMS MICROBIOLOGY LETTERS | 1996年 / 138卷 / 2-3期
关键词：
Streptococcus pneumoniae; teichoic acid; lipoteichoic acid; choline metabolism; choline kinase;
D O I：
10.1016/0378-1097(96)00086-9
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The choline-containing teichoic and lipoteichoic acids play an important part in cell wall metabolism of Streptococcus pneumoniae. We propose that a choline kinase enzyme has a role in the synthesis of these antigens. The presence of this enzyme was demonstrated in cell free extracts of S. pneumoniae by measuring the fall in ATP concentration due to phosphorylation of choline. Genomic DNA of S. pneumoniae hybridised with a probe consisting of an internal fragment of the choline kinase gene of Saccharomyces cerevisiae and one consisting of the choline binding domain of lytA.
引用
收藏
页码：141 / 145
页数：5
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