A new synthetic strategy for catechin-class polyphenols: concise synthesis of (-)-epicatechin and its 3-O-gallate

被引：33

作者：

Stadlbauer, Sven ^{[1
]}

Ohmori, Ken ^{[1
]}

Hattori, Fumihiko ^{[1
]}

Suzuki, Keisuke ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 67期

基金：

日本学术振兴会;

关键词：

GREEN TEA; EPIGALLOCATECHIN-3-GALLATE EGCG; ENANTIOSELECTIVE SYNTHESIS; GALLATE; EPIMERIZATION; CYCLIZATION; TANNINS; VIRUS;

D O I：

10.1039/c2cc33704e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Concise synthesis of (-)-epicatechin and its 3-O-gallate is described, illustrating efficacy of the new strategy for catechin-class polyphenols based on assembly of lithiated fluorobenzene and epoxy alcohol followed by a pyran cyclization. 1,3,5-Trifluorobenzene serves as the A-ring equivalent for functionalization and the pyran annulation.

引用

页码：8425 / 8427

页数：3

共 2 条

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