On-chip temperature gradient liquid chromatography

被引：5

作者：

Shih, CY ^{[1
]}

Chen, Y ^{[1
]}

Xie, J ^{[1
]}

He, Q ^{[1
]}

Tai, YC ^{[1
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

来源：

MEMS 2005 Miami: Technical Digest | 2005年

关键词：

D O I：

10.1109/MEMSYS.2005.1454046

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We report here the first MEMS temperature-programmable high pressure parylene column with integrated thermal isolation and electrochemical sensor for on-chip temperature gradient liquid chromatography. Two sets of devices for different high performance liquid chromatography (HPLC) criteria were fabricated. The separation and detection of derivatized amino acids sample was successfully demonstrated. Compared with other temperature gradient HPLC systems which use "macro oven" to generate temporal temperature gradient in the column, our device's thermal performance is greatly improved by orders of magnitude without the sacrifice of chromatography quality.

引用

页码：782 / 785

页数：4

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