Preparation of phthalocyanine bonded silica gel for the separation of phthalocyanine isomers

Tri-beta-(octyl-l-thiol)-beta-sulfamide-phthalocyanine copper bonded silica gel, which can be used as stationary phase of high performance liquid chromatography, was prepared and characterized. The prepared stationary phase can clearly separate the four isomers of some tetraalkoxy substituted metalophthalocyanines. For tetraalkoxysubstituted phthalocyanines free from metal, the four isomers can also be differentiated. Compared with the commercial C-18 column (VERTEX Eurospher), on which only two peaks were distinguished for the four isomers, the phthalocyanine-bonded silica gel column is more effective in separation of isomers of some substituted phthalocyanines.