Adiponectin resistance in skeletal muscle: pathophysiological implications in chronic heart failure

被引：73
|
作者：
Sente, Tahnee [1 ,2 ]
Van Berendoncks, An M. [1 ,2 ]
Hoymans, Vicky Y. [1 ,2 ]
Vrints, Christiaan J. [1 ,2 ]
机构：
[1] Univ Antwerp Hosp, Lab Cellular & Mol Cardiol, Edegem, Belgium
[2] Univ Antwerp, Dept Translat Pathophysiol Res, Cardiovasc Dis, Antwerp, Belgium
来源：
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE | 2016年 / 7卷 / 03期
关键词：
Chronic heart failure; Skeletal muscle; Wasting; Adiponectin resistance; PRESERVED EJECTION FRACTION; MOLECULAR-WEIGHT ADIPONECTIN; VENTRICULAR ASSIST DEVICE; CORONARY-ARTERY-DISEASE; ACTIVATED PROTEIN-KINASE; INDEPENDENT RISK-FACTOR; PLASMA ADIPONECTIN; INSULIN-RESISTANCE; SERUM ADIPONECTIN; CARDIOVASCULAR-DISEASE;
D O I：
10.1002/jcsm.12086
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Skeletal muscle wasting is a common complication of chronic heart failure (CHF) and linked to poor patient prognosis. In recent years, adiponectin was postulated to be centrally involved in CHF-associated metabolic failure and muscle wasting. This review discusses current knowledge on the role of adiponectin in CHF. Particular emphasis will be given to the complex interaction mechanisms and the intracellular pathways underlying adiponectin resistance in skeletal muscle of CHF patients. In this review, we propose that the resistance process is multifactorial, integrating abnormalities emanating from insulin signalling, mitochondrial biogenesis, and ceramide metabolism.
引用
收藏
页码：261 / 274
页数：14
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