In Vitro Evidence for the Protective role of Sida rhomboidea. Roxb Extract Against LDL Oxidation and Oxidized LDL-Induced Apoptosis in Human Monocyte-Derived Macrophages

被引：19
|
作者：
Thounaojam, Menaka C. [1 ]
Jadeja, Ravirajsinh N. [1 ]
Devkar, Ranjisinh V. [1 ]
Ramachandran, A. V. [1 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, Fac Sci, Div Phytotherapeut & Metab Endocrinol, Dept Zool, Vadodara 390002, Gujarat, India
来源：
CARDIOVASCULAR TOXICOLOGY | 2011年 / 11卷 / 02期
关键词：
S; rhomboidea; Roxb; LDL oxidation; Macrophage apoptosis; Oxidative stress; Atheorsclerosis; MITOCHONDRIAL DYSFUNCTION; LIPOPROTEIN OXIDATION; MEDIATED OXIDATION; LEAF EXTRACT; ANTIOXIDANT; CHOLESTEROL; SUPPLEMENTATION; PRODUCTS; MICE;
D O I：
10.1007/s12012-011-9110-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.
引用
收藏
页码：168 / 179
页数：12
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