A nonacid degradable linker for solid-phase synthesis

被引：6
|
作者：
Colombo, Aina
De la Figuera, Natalia
Fernandez, Joan Carles
Fernandez-Forner, Dolors
Albericio, Fernando
Forns, Pilar
机构：
[1] Almirall Barcelona Sci Pk Unit, E-08028 Barcelona, Spain
[2] Res Ctr, Almirall & Prodesfarma, E-08024 Barcelona, Spain
[3] Univ Barcelona, Inst Res Biomed, Barcelona Sci Pk, E-08028 Barcelona, Spain
[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 21期
关键词：
D O I：
10.1021/ol701879s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis and applications of two new nonacid degradable linkers as an alternative to the Wang linker for solid-phase synthesis are described. Resin from linker 2 looks superior to linker 1 in terms of yields for both anchoring of the first building block and cleavage and in terms of higher purity of the final product. Use of linker 2 avoids side reactions associated with the use of Wang resin due to an undesired cleavage during final acid treatment.
引用
收藏
页码：4319 / 4322
页数：4
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