Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation

被引:3
|
作者
Perciani, Catia T. [1 ]
Farah, Bashir [2 ]
Kaul, Rupert [1 ,3 ,4 ]
Ostrowski, Mario A. [1 ,3 ,5 ]
Mahmud, Salaheddin M. [6 ]
Anzala, Omu [2 ,7 ]
Jaoko, Walter [2 ,7 ]
MacDonald, Kelly S. [1 ,8 ,9 ]
Malogo, Roselyne [2 ]
Mahira, Rose
Mutua, Gaudensia
Atambo, Lydia
Nyaoke, Borna
Nyange, Jacquelyn
Omungo, Judith
Kotikot, Timothy
Gichuho, Mary W.
Ogutu, Hilda
Ndambuki, Rose
Museve, Emmanuel
Gakure, Hannah Nduta
Essendi, Dorothy
Mutiska, Elizabeth
Onsembe, Brian
Akiso, Matrona
Ogola, Simon
Wanjiku, Nelly
Langat, Robert
Indangasi, Jackton
Mwakisha, Naomi
Mwangi, Irene
Agwaya, Marion
Chirchir, Ruth
Alila, Richard
Said, Lewa
Wakonyo, James
Musanga, Mercy
Kamau, Catherine
Muriuki, Moses
Ndalamia, Jason
Ngeli, Catherine
Lusike, Laura
机构
[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada
[2] Univ Nairobi, Kenyan AIDS Vaccine Initiat, Inst Clin Res KAVI ICR, Nairobi, Kenya
[3] Univ Toronto, Dept Med, Toronto, ON, Canada
[4] Univ Hlth Network, Toronto, ON, Canada
[5] St Michaers Hosp, Keenan Res Ctr, Toronto, ON, Canada
[6] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Community Hlth Sci, Winnipeg, MB, Canada
[7] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya
[8] Univ Manitoba, Max Rady Coll Med, Dept Internal Med, Sect Infect Dis, Winnipeg, MB, Canada
[9] Univ Manitoba, Max Harty Coll Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada
来源
JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 02期
关键词
SIMIAN IMMUNODEFICIENCY VIRUS; SEXUALLY-TRANSMITTED INFECTIONS; HIGHLY PATHOGENIC SIV; TEST-OF-CONCEPT; HERPES-ZOSTER; BACTERIAL VAGINOSIS; IMMUNE ACTIVATION; GENITAL INFLAMMATION; EARLY EVENTS; FOLLOW-UP;
D O I
10.1172/JCI124473
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
BACKGROUND. Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny, since trials with adenovirus serotype 5-vectored (Ad5-vectored) HIV vaccine demonstrated increased HIV risk in individuals with pre-immunity to the vector that was thought to be associated with mucosal immune activation (IA). Therefore, given the prospect of developing an HIV/VZV chimeric vaccine, it is particularly important to define the impact of VZV vaccination on IA. METHODS. Healthy VZV-seropositive Kenyan women (n = 44) were immunized with high-dose live attenuated VZV vaccine, and we assessed the expression on CD4(+) T cells isolated from blood, cervix, and rectum of IA markers including CD38 and HLA-DR and of markers of cell migration and tissue retention, as well as the concentration of genital and intestinal cytokines. A delayed-start group (n = 22) was used to control for natural variations in these parameters. RESULTS. Although immunogenic, VZV vaccination did not result in significant difference in the frequency of cervical activated (HLA-DR(+)CD38(+)) CD4(+) T cells (median 1.61%, IQR 0.93%-2.76%) at 12 weeks after vaccination when compared with baseline (median 1.58%, IQR 0.75%-3.04%), the primary outcome for this study. VZV vaccination also had no measurable effect on any of the IA parameters at 4, 8, and 12 weeks after vaccination. CONCLUSION. This study provides the first evidence to our knowledge about the effects of VZV vaccination on human mucosal IA status and supports further evaluation of VZV as a potential vector for an HIV vaccine.
引用
收藏
页码:875 / 886
页数:12
相关论文
共 50 条
  • [1] LIVE ATTENUATED VARICELLA-ZOSTER VACCINE
    GERSHON, AA
    REVIEWS OF INFECTIOUS DISEASES, 1980, 2 (03): : 393 - 407
  • [2] LIVE ATTENUATED VARICELLA VACCINE - EVIDENCE THAT THE VIRUS IS ATTENUATED AND THE IMPORTANCE OF SKIN-LESIONS IN TRANSMISSION OF VARICELLA-ZOSTER VIRUS
    TSOLIA, M
    GERSHON, AA
    STEINBERG, SP
    GELB, L
    JOURNAL OF PEDIATRICS, 1990, 116 (02): : 184 - 189
  • [3] Live Attenuated Varicella-Zoster Vaccine in Hematopoietic Stem Cell Transplantation Recipients
    Issa, Nicolas C.
    Marty, Francisco M.
    Leblebjian, Houry
    Galar, Alicia
    Shea, Margaret M.
    Antin, Joseph H.
    Soiffer, Robert J.
    Baden, Lindsey R.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (02) : 285 - 287
  • [4] Seroprevalence of varicella-zoster virus antibody and immunogenicity of live attenuated varicella vaccine in healthcare workers in Taiwan
    Chong, Chen Hui
    Liu, Chun-Eng
    Leong, Yin-Yee
    Liao, Siang-Ying
    Lai, Huei-Wen
    Lee, Yu-Lin
    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2023, 56 (02) : 274 - 281
  • [5] HUMORAL AND CELLULAR IMMUNE-RESPONSE TO VARICELLA-ZOSTER VIRUS IN CHILDREN INOCULATED WITH LIVE ATTENUATED VARICELLA VACCINE
    KUMAGAI, T
    CHIBA, Y
    FUJIWARA, M
    HANAZONO, H
    NAKAMURA, S
    CHIBA, S
    NAKAO, T
    TAKAHASHI, M
    BIKEN JOURNAL, 1980, 23 (03) : 135 - 141
  • [6] Varicella-zoster virus vaccine
    White, CJ
    CLINICAL INFECTIOUS DISEASES, 1997, 24 (05) : 753 - 761
  • [7] The Immunogenicity and Safety of Live Attenuated Varicella-zoster Virus Vaccine in Human Immunodeficiency Virus-infected Children
    Taweesith, Wattanee
    Puthanakit, Thanyawee
    Kowitdamrong, Ekasit
    Bunupuradah, Torsak
    Wongngam, Walaiporn
    Phasomsap, Chayapa
    Apornpong, Tanakorn
    Bouko, Channuwat
    Pancharoen, Chitsanu
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2011, 30 (04) : 320 - 324
  • [8] Live Attenuated Varicella Vaccine: Prevention of Varicella and of Zoster
    Gershon, Anne A.
    Gershon, Michael D.
    Shapiro, Eugene D.
    JOURNAL OF INFECTIOUS DISEASES, 2021, 224 : S387 - S397
  • [9] Live attenuated vaccine for the prevention of varicella-zoster virus infection: does it work, is it safe and do we really need it in the UK?
    Breuer, J
    JOURNAL OF MEDICAL MICROBIOLOGY, 2003, 52 (01) : 1 - 3
  • [10] Varicella vaccine and infection with varicella-zoster virus
    Vázquez, M
    Shapiro, ED
    NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (05): : 439 - 440