Transition metal-free synthesis of quinolino[2',3':3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones via cascade dehydrogenation and intramolecular N-arylation

被引：16
|
作者：
Shiri, Morteza [1 ]
Heravi, Majid M. [1 ]
Hamidi, Hoda [1 ]
Zolfigol, Mohammad A. [2 ]
Tanbakouchian, Zahra [2 ]
Nejatinezhad-Arani, Atefeh [1 ]
Shintre, Suhas A. [3 ]
Koorbanally, Neil A. [3 ]
机构：
[1] Alzahra Univ, Fac Phys & Chem, Dept Chem, Tehran 1993893973, Iran
[2] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Iran
[3] Univ KwaZulu Natal, Sch Chem & Phys, ZA-4000 Durban, South Africa
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2016年 / 13卷 / 12期
基金：
美国国家科学基金会;
关键词：
Quinoline; Quinazolinone; Intramolecular N-arylation; Cascade reaction; Polyheterocycles; Transition metal-free; CATALYZED COUPLING REACTIONS; ARYL HALIDES; COPPER(I)-CATALYZED SYNTHESIS; AQUEOUS-MEDIA; DERIVATIVES; BOND;
D O I：
10.1007/s13738-016-0942-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-(2-Chloroquinolin-3-yl)-3-(arylamino)-2,3-dihydroquinazolin-4(1H)-one was converted to quinolino[2',3':3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones in the presence of KOtBu in DMSO at room temperature. The present method has the advantages of easy conditions, construction of highly novel five heterocycles, transition metal-free conditions, cascade dehydrogenation and intramolecular N-arylation and good to high yield of products.
引用
收藏
页码：2239 / 2246
页数：8
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