Important risk factors for the development of food allergy and potential options for prevention

被引:10
|
作者
Koplin, Jennifer J. [1 ,2 ]
Allen, Katrina J. [1 ,3 ,4 ]
Tang, Mimi L. K. [1 ,3 ,4 ]
机构
[1] Murdoch Childrens Res Inst, Parkville, Vic, Australia
[2] Univ Melbourne, Sch Populat & Global Hlth, Parkville, Vic, Australia
[3] Royal Childrens Hosp, Parkville, Vic, Australia
[4] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia
基金
英国医学研究理事会;
关键词
Food allergy; risk factors; prevention; peanut allergy; eczema; vitamin D; allergenic foods; microbial exposure; INFANT-FEEDING GUIDELINES; VITAMIN-D INSUFFICIENCY; HUMAN GUT MICROBIOME; FECAL MICROBIOTA; EGG ALLERGY; 1ST YEAR; PREVALENCE; LACTATION; DIET; AGE;
D O I
10.1080/1744666X.2019.1546577
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction: Food allergy currently affects up to 10% of infants. Identification and implementation of effective food allergy prevention strategies is thus imperative. Areas covered: We focus on five food allergy risk factors/prevention strategies which have been or are currently being tested in randomized controlled trials: (1) timely introduction of allergenic foods into the infant diet; (2) maternal diet and consumption of allergenic foods during pregnancy and breastfeeding; (3) infant skin barrier and the role of moisturizers in early life; (4) infant Vitamin D levels and the role of Vitamin D supplementation; and (5) microbial exposure in early life. Expert commentary: Earlier introduction of allergenic foods, particularly peanut, in the infant diet has been shown to reduce food allergy. Novel intervention strategies, including infant vitamin D supplementation, maternal diet modifications, and moisturizing infants to improve skin barrier, are currently being tested in large-scale clinical trials. As results of these trials become available, we hope strategies that are both efficacious and cost-effective will be revealed and their implementation in the population, along with the timely introduction of allergenic foods, will reduce the burden of food allergy in future generations.
引用
收藏
页码:147 / 152
页数:6
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