Optimal measurement locations for diagnosis of aortic abnormalities in a lumped-parameter model of the systemic circulation using sensitivity analysis

The basic theme of this work is to identify the optimal measurement locations for pressure and flow in the systemic circulation to detect, aortic stenoses and aneurysms in early-stages of a disease. For this purpose, a linear elastic lumped parameter model of the fluid dynamical simulator, major arterial cardiovascular simulator (MACSim), is considered and global sensitivity analysis is applied to identify the better measurement locations for pressure and flow in the systemic circulation. The obtained results of sensitivity analysis provide insight that enable the experimentalists to optimize their experimental setups for detecting aortic stenoses and aneurysms using parameter estimation process. From the results, it is observed that the stenosis in the thoracic aorta can be identified from both pressure and flow at the location itself, nearby nodes, aorta ascendens, arcus aorta, arteria. subclavia and arteria. axillaris. On the other hand, the preferable measurement locations for abdominal aneurysms are locations themselves, nearby nodes and left/right leg of the body.