Arylation of benzyl amines with aromatic nitriles

被引：26

作者：

Lei, Yingjie ^{[1
]}

Yang, Ju ^{[1
]}

Qi, Rupeng ^{[1
]}

Wang, Shan ^{[1
]}

Wang, Rui ^{[1
]}

Xu, Zhaoqing ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Sch Basic Med Sci, 199 West Donggang Rd, Lanzhou 730000, Gansu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 84期

关键词：

ORGANIC ELECTRON-DONORS; CATALYZED REGIOSELECTIVE ARYLATION; C-H ARYLATION; PHOTOREDOX CATALYSIS; 1,1,3-TRIARYL-2-AZAALLYL ANIONS; RADICAL REACTIONS; C(SP(3))-H BONDS; BISPYRIDINYLIDENE; INHIBITORS; REDUCTION;

D O I：

10.1039/c8cc06408c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of C(sp(3))-H in benzyl amines provided a practical method for the synthesis of diarylmethylamines without the use of precious transition metal catalysts.

引用

页码：11881 / 11884

页数：4

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