The physiology of corticotropin-releasing hormone deficiency in mice

被引：35

作者：

Muglia, LJ ^{[1
]}

Jacobson, L

Weninger, SC

Karalis, KP

Jeong, KH

Majzoub, JA

机构：

[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA

[4] St Louis Childrens Hosp, St Louis, MO 63110 USA

[5] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

[6] Albany Med Coll, Dept Pharmacol & Neurosci, Albany, NY 12208 USA

[7] Childrens Hosp, Div Neurosci, Boston, MA 02115 USA

[8] Brigham & Womens Hosp, Div Endocrine Hypertens, Boston, MA 02115 USA

来源：

PEPTIDES | 2001年 / 22卷 / 05期

基金：

美国国家卫生研究院;

关键词：

adrenal; circadian rhythm; glucocorticoids; knockout mice; pituitary;

D O I：

10.1016/S0196-9781(01)00385-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A review of the generation and characterization of corticotropin-releasing hormone (CRH)-deficient mice is presented. The studies summarized demonstrate the central role of CRH in the pituitary adrenal axis response to stress, circadian stimulation, and glucocorticoid withdrawal. Additionally. pro-inflammatory actions of CRH at sites of local inflammation are given further support. In contrast, behavioral effects during stress that had been ascribed to CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress in CRH-deficient mice strongly suggests the importance of other, possibly as yet undiscovered, CRH-like molecules. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：725 / 731

页数：7

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