Association of ERK5 with MEK5 (upstream kinase of ERK5), but not ERK5 kinase activation, inhibits small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation), and prevents diabetes (DM)-mediated exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI)

被引：0
|
作者：
Shishido, Tetsuro [1 ]
Woo, Chang-Hoon [1 ]
Ding, Bo [1 ]
McMclain, Carolyn [1 ]
Lu, Zhilbo [1 ]
Xu, Haodong [1 ]
Yan, Chen [1 ]
Abe, Jun-ichi [1 ]
机构：
[1] Univ Rochester, Rochester, NY 14627 USA
来源：
CIRCULATION | 2007年 / 116卷 / 16期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：211 / 211
页数：1
相关论文
共 50 条
  • [1] Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: Implications for diabetic ventricular dysfunction after myocardial infarction
    Shishido, Tetsuro
    Woo, Chang-Hoon
    Ding, Bo
    McClain, Carolyn
    Molina, Carlos A.
    Yan, Chen
    Yang, Jay
    Abe, Jun-ichi
    CIRCULATION RESEARCH, 2008, 102 (11) : 1416 - 1425
  • [2] Blockade of diabetes (DM)-mediated p9ORSK activation reduces small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation) and DM-induced exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI)
    Shishido, Tetsuro
    Woo, Chang-Hoon
    Ding, Bo
    McMclain, Carolyn
    Lu, Zhibo
    Yan, Chen
    Xu, Haodong
    Abe, Jun-ichi
    CIRCULATION, 2007, 116 (16) : 101 - 101
  • [3] Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
    Lochhead, Pamela A.
    Tucker, Julie A.
    Tatum, Natalie J.
    Wang, Jinhua
    Oxley, David
    Kidger, Andrew M.
    Johnson, Victoria P.
    Cassidy, Megan A.
    Gray, Nathanael S.
    Noble, Martin E. M.
    Cook, Simon J.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [4] Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
    Pamela A. Lochhead
    Julie A. Tucker
    Natalie J. Tatum
    Jinhua Wang
    David Oxley
    Andrew M. Kidger
    Victoria P. Johnson
    Megan A. Cassidy
    Nathanael S. Gray
    Martin E. M. Noble
    Simon J. Cook
    Nature Communications, 11
  • [5] Impairment of ERK5 Nuclear Localization Restores Sensitivity to ERK5 Kinase Inhibitors
    Lombardi, Z.
    Gardini, L.
    Menconi, A.
    Tusa, I.
    Lulli, M.
    Rovida, E.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2023, 25 (06): : S63 - S64
  • [6] The MEK5/ERK5 Pathway in Health and Disease
    Paudel, Rupesh
    Fusi, Lorenza
    Schmidt, Marc
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)
  • [7] Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for ...
    Cook, Simon J.
    Tucker, Julie A.
    Lochhead, Pamela A.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2020, 48 (05) : 1859 - 1875
  • [8] Bone and Extracellular Signal-Related Kinase 5 (ERK5)
    Wen, Lei
    Liu, Zirui
    Zhou, Libo
    Liu, Zhongcheng
    Li, Qingda
    Geng, Bin
    Xia, Yayi
    BIOMOLECULES, 2024, 14 (05)
  • [9] Identification of pharmacological inhibitors of the MEK5/ERK5 pathway
    Tatake, Revati J.
    O'Neill, Margaret M.
    Kennedy, Charles A.
    Wayne, Anita L.
    Jakes, Scott
    Wu, Di
    Kugler, Stanley Z., Jr.
    Kashem, Mohammed A.
    Kaplita, Paul
    Snow, Roger J.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 377 (01) : 120 - 125
  • [10] MEK5/ERK5 pathway: The first fifteen years
    Drew, Barbara A.
    Burow, Matthew E.
    Beckman, Barbara S.
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2012, 1825 (01): : 37 - 48
12345