CYTOTOXIC ACTIVITY OF SOME NOVEL SULFONAMIDE DERIVATIVES

被引：0
|
作者：
Ghorab, Mostafa M. [1 ,2 ]
Alsaid, Mansour S. [1 ]
Abdullah-Al-Dhfyan [3 ]
Arafa, Reem K. [4 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
[2] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Cairo, Egypt
[3] King Faisal Specialized Hosp, Res Ctr, Stem Cell & Tissue Reengn Program, Riyadh 11211, Saudi Arabia
[4] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
来源：
ACTA POLONIAE PHARMACEUTICA | 2015年 / 72卷 / 01期
关键词：
synthesis; sulfonamides; anticancer activity; CARBONIC-ANHYDRASES; ANTICANCER; DRUG; ANTIBACTERIAL;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The versatile synthons 2-chloro-N-(4-sulfamoylphenypacetamides la,b were used as a key intermediates for the synthesis of sulfonamide derivatives with adamantyl 2, indene 3, morpholinophenyl 4, pipronyl 5, benzothiazole 6-8, pyrazole 9, thiadiazole 10, 11, quinoline 12, isoquinoline 13, thiazoles 14-19, acrylamides 20-24 and benzochromene 25 moieties via reaction with several nitrogen nucleophiles. The newly synthesized compounds were screened in vim, for their anticancer activity against breast cancer (MDA-MB-231) and colon cancer (HT-29) cell lines. Compound 17 was found to be the most potent against breast cancer cell lines with 1050 value 66.6 mu M compared with the reference drug 5-fluorouracil with IC50 value 77.28 mu M.
引用
收藏
页码：79 / 87
页数：9
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