Biomolecular recognition based on single gold nanoparticle light scattering

被引：639
|
作者：
Raschke, G
Kowarik, S
Franzl, T
Sonnichsen, C
Klar, TA
Feldmann, J
Nichtl, A
Kürzinger, K
机构：
[1] Univ Munich, Dept Phys, Photon & Optoelect Grp, D-80799 Munich, Germany
[2] Univ Munich, CeNS, D-80799 Munich, Germany
[3] Roche Diagnost GmbH, D-82372 Penzberg, Germany
来源：
NANO LETTERS | 2003年 / 3卷 / 07期
关键词：
D O I：
10.1021/nl034223+
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for biomolecular recognition is reported using light scattering of a single gold nanoparticle functionalized with biotin. Addition of streptavidin and subsequent specific binding events alter the dielectric environment of the nanoparticle, resulting in a spectral shift of the particle plasmon resonance. As we use single nanoparticles showing a homogeneous scattering spectrum, spectral shifts as small as 2 meV can be detected.
引用
收藏
页码：935 / 938
页数：4
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