Therapeutic Approaches to Target Inflammation in Type 2 Diabetes

被引：101

作者：

Goldfine, Allison B. ^{[1
,2
]}

Fonseca, Vivian ^{[3
]}

Shoelson, Steven E. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA

[3] Tulane Univ, Dept Med, Endocrinol Sect, New Orleans, LA 70118 USA

来源：

CLINICAL CHEMISTRY | 2011年 / 57卷 / 02期

关键词：

C-REACTIVE PROTEIN; NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; SODIUM-SALICYLATE; CARDIOVASCULAR-DISEASE; GLYCEMIC CONTROL; IKK-BETA; RANDOMIZED-TRIAL; STATIN THERAPY; OBESE SUBJECTS;

D O I：

10.1373/clinchem.2010.148833

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

BACKGROUND: Chronic inflammation may participate in the pathogenesis of insulin resistance, type 2 diabetes, and cardiovascular disease and may be a common denominator that links obesity to these disease states. CONTENT: Epidemiologic studies have linked inflammatory biomarkers to incident diabetes and cardiovascular disease risk. Cellular and animal studies have provided support to the idea that inflammation mediates these disease processes, providing impetus to pharmacologically target these pathways for disease treatment and prevention. We review clinical strategies to target inflammation, with a focus on the antiinflammatory and antihyperglycemic effects of salicylates. SUMMARY: The evolving concept of diet-induced obesity driving insulin resistance, type 2 diabetes, and cardiovascular disease through immunologic processes provides new opportunities for the use of antiinflammatory strategies to correct the metabolic consequences of excess adiposity. (C) 2010 American Association for Clinical Chemistry

引用

页码：162 / 167

页数：6

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