Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review

被引：33

作者：

Steglich, Patrick ^{[1
,2
]}

Lecci, Giulia ^{[1
]}

Mai, Andreas ^{[1
,2
]}

机构：

[1] IHP Leibniz Inst Innovat Mikroelekt, D-15236 Frankfurt, Oder, Germany

[2] Tech Hsch Wildau, Dept Photon, D-15745 Wildau, Germany

来源：

SENSORS | 2022年 / 22卷 / 08期

关键词：

surface-plasmon resonance; photonic integrated circuits; biosensor; surface functionalization; label-free detection; LABEL-FREE BIOSENSORS; SLOT WAVE-GUIDES; OPTICAL BIOSENSORS; VIRUS DETECTION; RING-RESONATOR; MULTIPLEXED DETECTION; INFLUENZA-VIRUS; BEER SAMPLES; STRIP; CHIP;

D O I：

10.3390/s22082901

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance.

引用

页数：19

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