The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

被引：43

作者：

Apostolovic, D. ^{[1
,2
]}

Sanchez-Vidaurre, S. ^{[1
,2
]}

Waden, K. ^{[1
,2
]}

Curin, M. ^{[3
]}

Grundstrom, J. ^{[1
,2
]}

Gafvelin, G. ^{[4
]}

Velickovic, T. Cirkovic ^{[5
]}

Gronlund, H. ^{[4
]}

Thomas, W. R. ^{[6
]}

Valenta, R. ^{[3
]}

Hamsten, C. ^{[1
,2
,7
]}

van Hage, M. ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Med Solna, Immunol & Allergy Unit, Solna L2 04, SE-17176 Stockholm, Sweden

[2] Karolinska Univ Hosp, Solna L2 04, SE-17176 Stockholm, Sweden

[3] Med Univ Vienna, Div Immunopathol, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[4] Karolinska Inst, Therapeut Immune Design Unit, CMM, Dept Clin Neurosci, Stockholm, Sweden

[5] Univ Belgrade, Ctr Excellence Mol Food Sci, Fac Chem, Belgrade, Serbia

[6] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Perth, WA, Australia

[7] Karolinska Inst, Ctr Inflammatory Dis, Stockholm, Sweden

来源：

ALLERGY | 2016年 / 71卷 / 10期

基金：

奥地利科学基金会; 瑞典研究理事会;

关键词：

Can f 1; cat allergy; cross-reactivity; dog allergy; Fel d 7; T-CELL RECOGNITION; CRYSTAL-STRUCTURE; FURRY ANIMALS; ALLERGENS; SENSITIZATION; PATTERNS; INSIGHTS; IGE;

D O I：

10.1111/all.12955

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.

引用

页码：1490 / 1495

页数：6

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