An Old NSAID Revisited: Crystal Structure of Aldose Reductase in Complex with Sulindac at 1.0 Å Supports a Novel Mechanism for its Anticancer and Antiproliferative Effects

被引：7
|
作者：
Steuber, Holger [1 ]
机构：
[1] Proteros Biostruct GmbH, D-82152 Martinsried, Germany
来源：
CHEMMEDCHEM | 2011年 / 6卷 / 12期
关键词：
aldose reductase; antitumor agents; crystal structures; enzyme inhibition; sulindac; CELL-PROLIFERATION; PHASE-TRANSITION; INHIBITION; GROWTH; RETINA; LENS;
D O I：
10.1002/cmdc.201100374
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2155 / 2157
页数：3
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