Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin

被引：13
|
作者：
Ravindra, S. [1 ]
Varaprasad, K. [1 ]
Reddy, N. Narayana [1 ]
Vimala, K. [1 ]
Raju, K. Mohana [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Dept Polymer Sci & Technol, Synthet Polymer Lab, Anantapur 515055, Andhra Pradesh, India
来源：
JOURNAL OF POLYMERS AND THE ENVIRONMENT | 2011年 / 19卷 / 02期
关键词：
Solvent evaporation; Ciprofloxacin; Biodegradable microspheres; Controlled release; DELIVERY-SYSTEMS; DRUG-DELIVERY; INDOMETHACIN; MICELLES; OXIDE);
D O I：
10.1007/s10924-011-0290-8
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7.4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.
引用
收藏
页码：413 / 418
页数：6
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