Neural network and genetic algorithm aided combinatorial catalysis tool using 96-well microplate system - Optimization of cu catalyst for methanol synthesis at 1MPa

Recently combinatonal approach to catalyst development and optimization attracts much attention. We developed combinatorial tool based on 96-well microplate system to optimize Cu catalyst for methanol synthesis from syngas at 1MPa. After the catalysts were prepared in 96-deep well microplate by co-precipitation using liquid handler, they were arranged in 96-well microplate made of aluminum placed in high pressure HTS reactor Produced methanol was detected by 96-well microphite reader After neural network mapped the activity as a function of catalyst component optimization was successfully performed using genetic algorithm. The Cu catalyst was optimized for high CO2 tolerance.