Photopolymerizable degradable polyanhydrides with osteocompatibility

被引:152
|
作者
Anseth, KS
Shastri, VR
Langer, R [1 ]
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] Univ Colorado, Dept Chem Engn, Boulder, CO 80309 USA
关键词
degradable networks; bone substitutes; drug delivery;
D O I
10.1038/6152
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
We have developed a new family of photopolymerizable, methacrylated anhydride monomers and oligomers that combine high strength, controlled degradation, and photoprocessibility in a singular system. Networks with degradation times ranging from 1 week to nearly 1 year and that retain up to 90% of their tensile modulus at 40% mass loss are attainable. In vivo studies in rats have shown that these networks possess excellent osteocompatibility. These combined properties could offer many advantages in medical applications ranging from dentistry to orthopedics.
引用
收藏
页码:156 / 159
页数:4
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