Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy

被引：39
|
作者：
Zhang, Jin-Zhong
Xi, Xia
Gao, Ling
Kern, Timothy S.
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Ophthalmol, Cleveland, OH USA
[2] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA
[3] Shandong Prov Hosp, Jinan, Shandong, Peoples R China
来源：
CURRENT EYE RESEARCH | 2007年 / 32卷 / 10期
关键词：
aCE inhibitor; AT1; antagonist; leukostasis; losartan; VCAM-1;
D O I：
10.1080/02713680701584123
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: This study was conducted to examine the effect of angiotensin-converting enzyme ( ACE) inhibitors on the development of early stages of diabetic retinopathy. Methods: Rats were made diabetic by injection of streptozotocin and treated with the ACE inhibitor captopril and the AT1 antagonist losartan. The extent of capillary degeneration and leukostasis in the retina were determined. Results: Acellular capillaries and pericyte ghosts in the retina of diabetic animals were increased by similar to two- fold after 8 months of diabetes compared with the nondiabetic control, and captopril completely inhibited this capillary degeneration. Captopril and losartan also inhibited hyperglycemiainduced leukostasis at 6 weeks and 1 week in the retinal vasculature, respectively. In cultured retinal endothelial cells, angiotensin II-induced VCAM-1 expression was inhibited by losartan. Conclusions: Inhibition of the renin-angiotensin system can block retinal capillary degeneration and inflammation in the early stages of diabetic retinopathy.
引用
收藏
页码：883 / 889
页数：7
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