Effect of nonsteroidal anti-inflammatory drugs on lipid peroxidation by hydroxyl radical

被引：14
|
作者：
Tsujimoto, Y
Saitoh, K
Kashima, M
Shiozawa, A
Kozuka, M
Hashizume, H
Kimura, K
Yamazaki, M
Fujii, A
机构：
[1] Nihon Univ, Sch Dent Matsudo, Dept Endodont, Chiba 2718587, Japan
[2] Nihon Univ, Sch Dent Matsudo, Dept Pharmacol, Chiba 2718587, Japan
来源：
GENERAL PHARMACOLOGY | 1998年 / 31卷 / 03期
关键词：
NSAIDs; hydroxyl radical; lipid peroxidation; ESR; TBA;
D O I：
10.1016/S0306-3623(98)00044-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Effects of acetaminophen and sodium salicylate on hydoxyl radical elimination were studied using an electron-spin-resonance spin-trapping method. The effects of these agents on lipid peroxidation of the human erythrocyte membrane were also investigated by the thiobarbituric acid method. 2. Acetaminophen and sodium salicylate depressed hydroxyl radical generated by Cu2+/H2O2. 3. Acetaminophen inhibited Cu2+/H2O2-dependent lipid peroxidation; however, sodium salicylate enhanced Cu2+/H2O2-dependent lipid peroxidation. GEN PHARMAC 31;3:405-408, 1998. (C) 1998 Elsevier Science Inc.
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页码：405 / 408
页数：4
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