Marine Actinomycetes-derived Natural Products

被引：25

作者：

Yang, Chengfang ^{[1
]}

Qian, Rui ^{[1
]}

Xu, Yao ^{[1
]}

Yi, Junxi ^{[1
]}

Gu, Yiwen ^{[1
]}

Liu, Xiaoyu ^{[1
]}

Yu, Haobing ^{[1
]}

Jiao, Binghua ^{[1
]}

Lu, Xiaoling ^{[1
]}

Zhang, Wei ^{[2
,3
]}

机构：

[1] Second Mil Med Univ, Coll Basic Med Sci, Dept Biochem & Mol Biol, 800 Xiangyin Rd, Shanghai 200433, Peoples R China

[2] Flinders Univ S Australia, Ctr Marine Bioprod Dev, 4-21,Level 4 Hlth Sci Bldg,Registry Rd, Adelaide, SA 5042, Australia

[3] Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA, Australia

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2019年 / 19卷 / 31期

基金：

国家重点研发计划;

关键词：

Marine actinomycetes; Secondary metabolites; Antibacterial activity; Antiviral activity; Cytotoxic activity; Lead compound; STREPTOMYCES SP; SECONDARY METABOLITES; A-C; STRUCTURE ELUCIDATION; MICROMONOSPORA SP; ANGUCYCLINE GLYCOSIDES; PHENOLIC POLYKETIDES; H-J; SEA; ANTIBACTERIAL;

D O I：

10.2174/1568026619666191114102359

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Actinomycetes is an abundant resource for discovering a large number of lead compounds, which play an important role in microbial drug discovery. Compared to terrestrial microorganisms, marine actinomycetes have unique metabolic pathways because of their special living environment, which has the potential to produce a variety of bioactive substances. In this paper, secondary metabolites isolated from marine actinomycetes are reviewed (2013-2018), most of which exhibited cytotoxic, antibacterial, and antiviral biological activities.

引用

页码：2868 / 2918

页数：51

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