Synthesis and biological evaluation of himanimide C and unnatural analogues

被引：33
|
作者：
Sellès, P [1 ]
机构：
[1] SYNGENTA Crop Protect AG, Res Chem, CH-4002 Basel, Switzerland
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 04期
关键词：
D O I：
10.1021/ol047664o
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Recently isolated himanimide C (1) can be prepared via a short, flexible, and stereoselective synthesis using a copper-mediated tandem vicinal difunctionalization of dimethyl acetylenedicarboxylate (DMAD, 8) as a key step. The flexibility of the synthesis is exemplified by the preparation of new unnatural himanimide analogues in order to investigate the fungicidal potency of this new family.
引用
收藏
页码：605 / 608
页数：4
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