Management of Myositis-Related Interstitial Lung Disease

被引：100
|
作者：
Morisset, Julie [1 ]
Johnson, Cheilonda [2 ]
Rich, Eric [3 ]
Collard, Harold R. [1 ]
Lee, Joyce S. [4 ]
机构：
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[2] Johns Hopkins Univ, Div Pulm & Crit Care Med, Baltimore, MD USA
[3] CHU Montreal, Dept Med, Montreal, PQ, Canada
[4] Univ Colorado Denver, Dept Med, Aurora, CO USA
来源：
CHEST | 2016年 / 150卷 / 05期
关键词：
interstitial lung disease; myositis; treatment; IDIOPATHIC INFLAMMATORY MYOPATHIES; LONG-TERM OUTCOMES; CHEST CT FINDINGS; MYCOPHENOLATE-MOFETIL; CLINICAL-FEATURES; INTRAVENOUS IMMUNOGLOBULIN; CYCLOPHOSPHAMIDE TREATMENT; RITUXIMAB THERAPY; POLYMYOSITIS; DERMATOMYOSITIS;
D O I：
10.1016/j.chest.2016.04.007
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Interstitial lung disease (ILD) is a frequent pulmonary manifestation and an important cause of morbidity and mortality in patients with idiopathic inflammatory myopathy. Myositis-related ILD presents a therapeutic challenge for clinicians, as there are no available guidelines to help with management decisions. This review covers the existing evidence on the pharmacologic and nonpharmacologic management of myositis-related ILD, highlighting the lack of randomized controlled data to guide treatment. Given the absence of existing guidelines to inform treatment decisions, we provide a comprehensive summary, including dosing, side effects, and suggested monitoring of the commonly used immunosuppressive agents and a proposed treatment algorithm based on the existing literature.
引用
收藏
页码：1118 / 1128
页数：11
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