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Univ Toronto, Sunnybrook Hlth Sci Ctr, Mol & Cellular Biol Res & Odette Canc Ctr, Div Med Oncol, Toronto, ON M4N 3M5, Canada Univ Toronto, Sunnybrook Hlth Sci Ctr, Mol & Cellular Biol Res & Odette Canc Ctr, Div Med Oncol, Toronto, ON M4N 3M5, Canada