Incidence of Post-Operative Complications and Factors Influencing Their Occurrence in Patients with Sickle Cell Disease in a Low-Income Country: A Case Study of Cameroon

被引:0
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作者
Djomo Tamchom, Dominique [1 ,2 ,3 ,4 ]
Eposse Ekoube, Charlotte [5 ,6 ]
Essola, Basile [2 ,5 ]
Nga Nomo, Serge [7 ,8 ]
Benghiat, Fleur Samantha [2 ,9 ]
Van Obbergh, Luc [2 ,4 ]
机构
[1] Univ Buea, Fac Hlth Sci, Buea 63, Cameroon
[2] Free Univ Brussels, Fac Med, B-1070 Brussels, Belgium
[3] Douala Gynaecoobstetr & Paediat Hosp, Dept Anaesthesiol & Intens Care, Douala 7072, Cameroon
[4] Erasme Univ Hosp, Dept Anaesthesiol, B-1070 Brussels, Belgium
[5] Univ Douala, Fac Med & Pharmaceut Sci, Douala 2701, Cameroon
[6] Laquintinie Hosp, Sickle Cell Treatment Ctr, Douala 4035, Cameroon
[7] Higher Inst Med Technol, Yaounde 188, Cameroon
[8] Essos Hosp Ctr, Dept Anaesthesiol & Intens Care, Yaounde 441, Cameroon
[9] Erasme Univ Hosp, Dept Haematol, B-1070 Brussels, Belgium
关键词
patient with sickle cell disease; anaesthesia; surgery; post-operative complications; incidence; LAPAROSCOPIC CHOLECYSTECTOMY; PREOPERATIVE TRANSFUSION; CHILDREN; MANAGEMENT; SURGERY; CHOLELITHIASIS; HYDROXYUREA; ADULTS;
D O I
10.3390/jcm11030780
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed to analyse post-operative complications and possible factors influencing their occurrence in the management of patients with sickle cell disease in a low-income country. We prospectively collected data regarding the management of patients with sickle cell disease requiring anesthesia for surgery in 11 Cameroonian hospitals from 1 May 2019 to 30 April 2021. The data were analysed using descriptive statistics and a binary logistic regression was used to determine the dependence between the variables. A total of 124 patients with sickle cell disease were enrolled; 64 were male and 60 female, giving a sex ratio of 0.93. The rate of post-operative complications was 23.4% (29/124) and the death rate was 3.2% (4/124). The female subjects had more complications than the male subjects p < 0.05. The number of vaso-occlusive crises experienced per year showed a significant impact on the occurrence of post-operative complications p < 0.05. Laparoscopic surgery had fewer post-operative complications 5/46 (10.9%) than laparotomy 14/43 (32.5%). The surgical technique for the abdominal procedures had a significant impact on the occurrence of post-operative complications p < 0.05. The type of surgery (p = 0.198) and the anaesthesia technique (p = 0.225) did not show a significant impact on the occurrence of post-operative complications. Particular attention should be paid to female patients with sickle cell disease as they are more likely to experience post-operative complications, as well as to the frequency of vaso-occlusive crises, which are also predictive of post-operative complications. Opting for laparoscopic surgery whenever possible would help to reduce post-operative complications.
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页数:10
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