Onset of coeliac disease: a prospective longitudinal study

被引:30
|
作者
Pittschieler, K [1 ]
Gentili, L [1 ]
Niederhofer, H [1 ]
机构
[1] Reg Hosp, Dept Paediat, IT-39100 Bolzano, Italy
关键词
coeliac disease; onset; screening;
D O I
10.1080/08035250310005332
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Aim: To make a prospective assessment of close family members of patients with coeliac disease (CD) by testing their endomysium (EMA) and antigliadin antibodies once a year over a period of 12 y and to investigate whether and when they would develop a positive serology for CD while on a gluten-containing diet. Methods: Since first-degree relatives of CD patients have a high prevalence of CD, we screened 92 children and adolescents, all first-degree relatives of coeliac patients, for EMA and total IgA antibodies, once a year. Results: Among 11 relatives, at the time of the first screening, 6 already had a positive serology and histology for CD, while 5 became positive only after a period of 2 to 5 y of negative testing. The jejunal mucosa biopsy of these five relatives with retarded positive serology for CD showed a flat mucosa in four of them and a partial villous atrophy in one. They were all HLA DQ2 positive and clinically silent for CD. Conclusion: CD can manifest itself after years of negative serological testing.
引用
收藏
页码:1149 / 1152
页数:4
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