Improved synthesis of the ORL antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)

被引：1
|
作者：
Carroll, F. Ivy [1 ]
Brieaddy, Lawrence E. [1 ]
机构：
[1] Res Triangle Inst, Ctr Organ & Med Chem, Res Triangle Pk, NC 27709 USA
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 12期
关键词：
antagonist; chiral auxiliary; J-113397; ORL-1; synthesis;
D O I：
10.1080/00397910801997579
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical synthesis of optically pure 1-[(3R,4R)-1-cyclooctylmethyl-3-ethoxycarbonyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) was developed that avoids the use of chiral columns.
引用
收藏
页码：1926 / 1930
页数：5
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