Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities

A series of new sulfonylurea derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to explore the possibilities of some altered biological actions such as antibacterial, antifungal and antioxidant activities (DPPH, H2O2 and IC50 values). Structures of these compounds have been well established by a, H-1 and C-13 NMR, mass spectra and elemental analysis. Among the compounds 9c and 9j show promising antimicrobial activity. Compounds 9a, 9j and 9d exhibit good antioxidant activity with lowest IC50 values and close to the standard drug, ascorbic acid. Biological data reveals that sulfonylurea derivatives show good antioxidant activity rather than antimicrobial activity.